1 2 Microevolution and Patterns of Dissemination of the JP 2 Clone of 3 Aggregatibacter ( Actinobacillus ) actinomycetemcomitans 4 5 6 7
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منابع مشابه
Microevolution and Patterns of Dissemination of the JP 2 Clone of 3 Aggregatibacter ( Actinobacillus ) actinomycetemcomitans 4 5 6 7
1 Department of Community Oral Health and Pediatric Dentistry, School of Dentistry, and 2 Institute 10 of Medical Microbiology and Immunology, Faculty of Health Science, University of Aarhus, 11 Denmark 12 13 14 Running head: Microevolution of the JP2 clone 15
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The JP2 clone of Actinobacillus actinomycetemcomitans is associated with early-onset periodontitis in certain ethnic populations of African origin. Here, we describe and evaluate a set of primers for PCR to assay for the presence of A. actinomycetemcomitans and to discriminate between JP2-like strains and other genotypes in subgingival plaque samples.
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8 REVIEW OF THE LITERATURE 10 1. Periodontitis 10 1.1 General characteristics and classification 10 1.2 Oral biofilms 10 1.3 Actinobacillus actinomycetemcomitans in periodontitis 12 2. Evolutionary lineages of A. actinomycetemcomitans 14 2.1 Population structure 14 2.2 Natural transformation 16 2.3 Intraspecies diversity 17 2.4 Serotypes and serotype-specific antigens 19 2.5 Serotypes vs. genot...
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The bacterium Actinobacillus actinomycetemcomitans has been implicated in the pathogenesis of juvenile periodontitis as the etiologic agent on the basis of several lines of circumstantial evidence. A matter of extensive debate is whether A. actinomycetemcomitans is an exogenous contagious pathogen or an opportunistic pathogen that resides in the normal oral microflora. Here we show evidence of ...
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This longitudinal study evaluated the response to periodontal treatment by subjects infected with either JP2 (n = 25) or non-JP2 (n = 25) Aggregatibacter (Actinobacillus) actinomycetemcomitans. Participants were treated during the first 4 months by receiving (i) scaling and root planing, (ii) systemic antibiotic therapy, and (iii) periodontal surgery. Probing depth (PD), clinical attachment lev...
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