A new synthesis of N-alkyl 3-acetyl-4-methoxycarbonylmethyl-2-methyl-1,4-dihydropyridines utilizing sec-aminodienyl esters with acetylacetone.
نویسندگان
چکیده
The reactions of sec-aminodienyl esters 3 with acetylacetone (4) afforded N-alkyl 3-acetyl-4-methoxycarbonylmethyl-2-methyl-1,4-dihydropyridines 5 and enamines 6, providing a new azaelectrocyclization reaction.
منابع مشابه
A new synthesis of N-alkyl 4-methyl-1,4-dihydropyridines utilizing sec-aminodienyl esters with crotonaldehyde.
The reactions of sec-aminodienyl esters 3 with crotonaldehyde (4) afforded N-alkyl 3-[2-(methoxycarbonyl)ethenyl]-4-methyl-1,4-dihydropyridines 5, providing a new azaelectrocyclization reaction.
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A simple, green synthesis of N-alkyl-3-acetyl-2-methylpyrrole derivatives using ZnO nanoparticles from the three component reaction of aliphatic amines, acetylacetone (as a 1,3-dicarbonyl compound) and α-haloketones under solvent-free condition is described.
متن کاملCatalytic Synthesis N-alkyl-3-acetyl-2-methylpyrroles using ZnO Nanostructure
A simple, green synthesis of N-alkyl-3-acetyl-2-methylpyrrole derivatives using ZnO nanoparticles from the three component reaction of aliphatic amines, acetylacetone (as a 1,3-dicarbonyl compound) and α-haloketones under solvent-free condition is described.
متن کاملSynthesis of 2-Mono and 2,6-Disubstituted Methyl-1,4-Dihydropyridines
The 2-mono and 2,6-disubstituted methyl-1,4-dihydropyridines were synthesized by reaction of morpholine, thiophenol, 8-hydroxyquinoline, 2-naphthol and 2-mercopto-1-methyl imidazole with the 2-mono bromo and 2,6-dibromo-1,4-dihidropyridines.
متن کاملDirect Aminolysis of Ethoxycarbonylmethyl 1,4-Dihydropyridine-3-carboxylates.
The ethoxycarbonylmethyl esters of 1,4-dihydropyridines were directly converted into carbamoylmethyl esters in the presence of 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) in good to excellent yields under mild conditions. The use of TBD is crucial for the successful aminolysis of ethoxycarbonylmethyl ester of 1,4-dihydropyridines with secondary amines as without it the reaction does not proceed a...
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ورودعنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 50 4 شماره
صفحات -
تاریخ انتشار 2002