Nagstatin, a new inhibitor of N-acetyl-beta-D-glucosaminidase, produced by Streptomyces amakusaensis MG846-fF3. Taxonomy, production, isolation, physico-chemical properties and biological activities.
نویسندگان
چکیده
Nagstatin, a new inhibitor of N-acetyl-beta-D-glucosaminidase (NAG-ase) was discovered in the fermentation broth of Streptomyces amakusaensis MG846-fF3. It was purified by chromatography on Dowex 50W, Avicel and Sephadex LH-20 followed by the treatment of active carbon and then isolated as colorless powder. Nagstatin has the molecular formula of C12H17N3O6. It is competitive with the substrate, and the inhibition constant (Ki) was 1.7 x 10(-8) M.
منابع مشابه
Syntheses and glycosidase inhibiting activities of nagstatin analogs.
Sir: Nagstatin (1) is a novel A^-acetyl-jft-D-glucosaminidase inhibitor isolated from culture nitrates of Streptomyces amakusaensis, and is structurally a nitrogenous 7V-acetylgalactosamine analog fused with an imidazole ring.1} Recently, we have synthesized de-branched nagstatin analogs having different configurations and functionalities, and then determined the absolute structure of nagstatin...
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 45 9 شماره
صفحات -
تاریخ انتشار 1992