NO/cGMP signalling in platelets
نویسندگان
چکیده
Background NO/cGMP-signalling is important for the inhibition of platelet aggregation. The cGMP dependent protein kinase I plays thereby the key role in the signal cascade of NO/ cGMP. It is already known that the interaction of the cGKI substrate IRAG with the IP3RI is essential for the NO/ cGMP dependent inhibition of platelet aggregation. To specify the relevance of IRAG signalling for platelet function, IRAG deficient murine mutants were analysed. Diverse agonists like thrombin, thromboxane A2 and collagen induced platelet aggregation and granule secretion.
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