Chromosome Dynamics: New Light on Aurora B Kinase Function
نویسندگان
چکیده
Aurora B family kinases play an essential role in chromosome segregation and cytokinesis. Recent work suggests that the kinase activity is required for bipolar chromosome orientation, kinetochore assembly, spindle checkpoint and microtubule dynamics. Aurora B also has additional functions in chromosome condensation and cohesion.
منابع مشابه
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Shining new light on the function of Aurora A A urora A isn’t exactly a mystery protein, but researchers have struggled to determine its function. Hégarat et al. discovered that the kinase helps line up mitotic chromosomes and spurs disassembly of microtubules during anaphase, in collaboration with its cousin Aurora B. Studies on various cell types have furnished contradictory answers about wha...
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A family of serine/threonine kinase Aurora constitutes a key regulator in the orchestration of mitotic events. The human Aurora paralogues Aurora-A, Aurora-B, and Aurora-C have a highly conserved catalytic domain. Extensive studies on the role of Aurora-A and Aurora-B have revealed distinct localizations and functions in regulating mitotic processes, whereas little is known about Aurora-C. The ...
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ورودعنوان ژورنال:
- Current Biology
دوره 12 شماره
صفحات -
تاریخ انتشار 2002