Reduced expression of toll-like receptor 2 on peripheral monocytes in patients with chronic hepatitis B.
نویسندگان
چکیده
Persistent infection with hepatitis B virus (HBV) likely depends on viral inhibition of host defenses. We report that chronic hepatitis B e antigen-positive HBV infection is associated with a significant reduction in peripheral blood monocyte expression of Toll-like receptor 2, a key component of innate immunity, thereby providing a mechanism by which wild-type HBV may establish persistent infection.
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ورودعنوان ژورنال:
- Clinical and vaccine immunology : CVI
دوره 13 8 شماره
صفحات -
تاریخ انتشار 2006