Abstract P26. The Ratio And Time Effect: Administration Of Il-2-anti-il-2 Complexes Controls Vascularized Composite Allograft Survival.
نویسندگان
چکیده
METHODS: We performed the VCA model utilizing Balb/c mice as donor and C57bl/10 mice as recipient. Mice were divided randomly to 6 groups (n=15/group). Group A: control; Group B: post-Tx. IL-2C (inj. POD 0, 1, 2); Group C: Rapamycin (2mg/kg, 28days); Group D: Rapamycin plus post-Tx. IL-2C; Group E: pre-Tx. IL-2C (POD -5, -4, -3); Group F: Rapamycin plus pre-Tx. IL-2C. Signs of allograft rejection were monitored daily. General and local inflammation were assessed using flow-cytometry, qPCR and histopathology analysis.
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