Retinal Cannabinoids
نویسندگان
چکیده
Marijuana and the Endocannabinoids 1 Synthesis and Release 2 Inactivation 2 Receptors 2 Distribution and Function 2 Cannabinoids and Ocular Tissues 3 CannabinoidsdRetinal Anatomy 3 LocalizationdCannabinoid Receptors 4 LocalizationdSynthesizing and Catabolic Enzymes 4 CannabinoidsdRetinal Physiology 4 Effects on Transmitter Release 4 Effects on Ganglion Cells 5 Effects on Amacrine Cells 5 Effects on Bipolar Cells 5 Effects on Photoreceptors 5 CannabinoidsdDevelopment and Neuroprotection 5 Development 5 Regeneration 6 Conclusion 6 Further Reading 6 Relevant Websites 7
منابع مشابه
Endogenous and Synthetic Cannabinoids as Therapeutics in Retinal Disease
The functional significance of cannabinoids in ocular physiology and disease has been reported some decades ago. In the early 1970s, subjects who smoked Cannabis sativa developed lower intraocular pressure (IOP). This led to the isolation of phytocannabinoids from this plant and the study of their therapeutic effects in glaucoma. The main treatment of this disease to date involves the administr...
متن کاملThe arguments for and against cannabinoids application in glaucomatous retinopathy.
Glaucoma represents several optic neuropathies leading to irreversible blindness through progressive retinal ganglion cell (RGC) loss. Reduction of intraocular pressure (IOP) is known as the only modifiable factor in the treatment of this disorder. Application of exogenous cannabinoids to lower IOP has attracted attention of scientists as potential agents for the treatment of glaucoma. Accordin...
متن کاملThe Endocannabinoid System in the Retina: From Physiology to Practical and Therapeutic Applications
Cannabis is one of the most prevalent drugs used in industrialized countries. The main effects of Cannabis are mediated by two major exogenous cannabinoids: ∆9-tetrahydroxycannabinol and cannabidiol. They act on specific endocannabinoid receptors, especially types 1 and 2. Mammals are endowed with a functional cannabinoid system including cannabinoid receptors, ligands, and enzymes. This endoca...
متن کاملThe Endocannabinoid System as a Therapeutic Target in Glaucoma
Glaucoma is an irreversible blinding eye disease which produces progressive retinal ganglion cell (RGC) loss. Intraocular pressure (IOP) is currently the only modifiable risk factor, and lowering IOP results in reduced risk of progression of the disorder. The endocannabinoid system (ECS) has attracted considerable attention as a potential target for the treatment of glaucoma, largely due to the...
متن کاملNeuroprotective effects of the cannabinoid agonist HU210 on retinal degeneration.
Cannabinoids have been demonstrated to exert neuroprotective effects on different types of neuronal insults. Here we have addressed the therapeutic potential of the synthetic cannabinoid HU210 on photoreceptor degeneration, synaptic connectivity and functional activity of the retina in the transgenic P23H rat, an animal model for autosomal dominant retinitis pigmentosa (RP). In P23H rats admini...
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