Sequential Double “Clicks” toward Structurally Well‐Defined Heterogeneous N‐Glycoclusters: The Importance of Cluster Heterogeneity on Pattern Recognition In Vivo

نویسندگان

  • Liliya Latypova
  • Regina Sibgatullina
  • Akihiro Ogura
  • Katsumasa Fujiki
  • Alsu Khabibrakhmanova
  • Tsuyoshi Tahara
  • Satoshi Nozaki
  • Sayaka Urano
  • Kazuki Tsubokura
  • Hirotaka Onoe
  • Yasuyoshi Watanabe
  • Almira Kurbangalieva
  • Katsunori Tanaka
چکیده

Structurally well-defined heterogeneous N-glycoclusters are prepared on albumin via a double click procedure. The number of glycan molecules present, in addition to the spatial arrangement of glycans in the heterogeneous glycoclusters, plays an important role in the in vivo kinetics and organ-selective accumulation through glycan pattern recognition mechanisms.

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عنوان ژورنال:

دوره 4  شماره 

صفحات  -

تاریخ انتشار 2017