A global optimization approach for metabolic flux analysis based on labeling balances
نویسندگان
چکیده
The flux quantification step in metabolic flux analysis (MFA) includes the mathematical modeling of metabolism (based on both metabolite and isotope balancing) and its optimization, which minimizes a weighted distance between measurements and model predictions. When GC–MS is used for assessing the 13C-labeling in intracellular metabolites, the metabolic flux quantification problem originates a non-convex o p f t
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عنوان ژورنال:
- Computers & Chemical Engineering
دوره 29 شماره
صفحات -
تاریخ انتشار 2005