Hormone Anchored Metal Complexes. 1. Synthesis, Structure, Spectroscopy and In Vitro Antitumor Activity of Testosterone Acetate Thiosemicarbazone and its Metal Complexes
نویسندگان
چکیده
Testosterone acetate thiosemicarbazone (TATSC, 17-beta-hydroxyandrost-4-one acetate thiosemicarbazone) was synthesized and characterized by single crystal X-ray structure determination. The copper and platinum complexes of this steroid derivative were synthesized and characterized by spectroscopy and electrochemiatry. The in vitro activity of these compounds against human breast cancer cell line MCF-7 was tested. The highest activity was found for the [Pt(TATSC)Cl(1)] followed by [Cu(TATSC)Cl(2)] and the ligand in compariosn with cisplatin.
منابع مشابه
Synthesis, characterization, antioxidant and antimicrobial activities of a heptadentate N4O3-type Schiff base ligand and its metal complexes
Mo(III), Fe(III), Cd(II), Zn(II), Cu(II) complexes based on Tris[2-salicylaldeneimino)ethyl]amine (H3saltren) have been successfully synthesized. Newly prepared compounds have been characterized by 1H-NMR, 13C-NMR, IR and UV–VIS spectroscopy techniques. The spectral studies confirmed the ligand coordinates the metal ion to form complex via the oxygen and nitroge...
متن کاملSynthesis of New Schiff Base Ligand and Its Complexes in The Presence of Some Transition Metal Ion and Evaluation of Their Antibacterial Properties
ABSTRACT Background and objectives: Synthesis and characterization of several metal complexes (metal ions: Co2+, Ti4+ and Ce3+) of macroacyclic Schiff base ligand have been reported. The Schiff base ligand is prepared from the condensation reaction of 1, 4-di-(4-fluoro-2-aminophenoxy) butane with salicylaldehyde in ethanol. In addition, antibacterial ...
متن کاملSynthesis, characterization, antibacterial activity and molecular modeling studies of Ni(II) and Zn(II) complexes with phenylpyridylformamidine ligand
The Ni(II) and Zn(II) complexes with phenylpyridylformamidine (PhPyF) ligand, [Ni(PhPyF)Cl2] and [Zn(PhPyF)Cl2], have been prepared and investigated using different chemical techniques such as elemental analysis, molar conductance, FT-IR, UV-vis spectra and magnetic moment. The obtained chemical analysis data showed the formation of 1:1 (metal: ligand) ratio. The square planar and tetrahedral g...
متن کاملSynthesis , structure , spectroscopy and antitumor activity of hydroxy naphthoquinone thiosemicarbazone and its metal complexes against MCF - 7 human breast cancer cell line
Coordinately unsaturated metal complexes of the stoichiometry [M(HL)CI] and [Fe(HL)CI2].2H20 have been isolated (where M=Cu(II), Ni(II), Pd(lI) and PtClI); HL=tridentate anion of H2L 3). The X-ray crystal structure for 4-hydroxy-3methyl-I ,2-naphthoquinone-I-thiosemicarbazone, 3 has been determined which crystallizes in spacc group P2 1/c , a = 7.430(3), b = 10.794(3), c = 17.216(5) A, ~ =92.91...
متن کاملSynthesis and Evaluation of Antimicrobial Activity of Metal Complexes of 4-(2'-Hydroxy Phenyl Imino) Phenyl Sulphonamide
Keeping in view the promising potential of carbonic anhydrase inhibitor based antimicrobials and enhancement of carbonic anhydrase inhibitory activity by metal complexes of sulfonamides, with an aim to develop better antimicrobial agents we have attempted investigation of antimicrobial activity of metal complexes of 4-(2'-hydroxy phenyl imino) phenyl sulphonamide. Sulfanilamide was taken...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Metal-Based Drugs
دوره 6 شماره
صفحات -
تاریخ انتشار 1999