HGP44 induces protection against Porphyromonas gingivalis-Induced alveolar bone loss in mice.

نویسندگان

  • Kyotaro Muramatsu
  • Eitoyo Kokubu
  • Takahiko Shibahara
  • Katsuji Okuda
  • Kazuyuki Ishihara
چکیده

The protective effect of DNA vaccines expressing the Arg-gingipain A domain against bone loss induced by Porphyromonas gingivalis infection was investigated in a murine model. phgp44, which expresses the 44-kDa adhesion/hemagglutinin domain of Arg-gingipain A, prevented P. gingivalis-induced alveolar bone loss. The results indicate that phgp44 could be a candidate antigen for a vaccine against P. gingivalis infection.

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عنوان ژورنال:
  • Clinical and vaccine immunology : CVI

دوره 18 5  شماره 

صفحات  -

تاریخ انتشار 2011