Objective markers of drug effects on brain function from recordings of scalp potential in healthy volunteers
نویسنده
چکیده
In order to stress the importance of P300 responses in drug development, we describe the spatiotemporal characteristics of this objective, evoked event-related potential. These brain activations reflect mnemonic function, in which limbic structures play a role. It is demonstrated that a pharmacological challenge concerning, for example, the cholinergic system in young healthy volunteers induces modifications in P300 reminiscent of the aging brain. We use this type of observation to build a model in which it can be verified whether the deterioration can be counteracted by treatment with "cognition-enhancing" drugs. If we accept the extrapolation of the pharmacological effects to symptomatology, scalp potential analysis offers an appropriate tool for the study of drug interactions in early proof-of-concept models.
منابع مشابه
اثرات قلبی- عروقی نوسکاپین، آلکالوئید ضد سرفه تریاک
Background: Noscapine is a phtalideisoquinoline alkaloid with known anti-tussive properties. Recently, some other pharmacological effects and new potential clinical applications have been proposed for the drug. Since there is no data regarding its cardiovascular effects, cardiovascular actions of Noscapine were investigated in the present study. Methods: In this experimental study,�the effe...
متن کاملEfficacy of Tinospora cordifolia on Learning and Memory in Healthy Volunteers: A Double-Blind, Randomized, Placebo Controlled Study
Background. Tinospora cordifolia, an Indian medicinal plant, has been reported to have beneficial effects on disorders like peptic ulcer, hepatobiliary disorders, rheumatism, infectious diseases etc. It enhances cognition in normal rats and successfully overcomes cyclosporine induced memory deficit. Methods. Thirty healthy volunteers of age 18-30 years received Tinospora cordifolia (500 mg of p...
متن کاملLocalization of MDMA-induced brain activity in healthy volunteers using low resolution brain electromagnetic tomography (LORETA).
3,4-Methylenedioxymethamphetamine (MDMA; 'Ecstasy') is a psychostimulant drug producing heightened mood and facilitated social communication. In animal studies, MDMA effects are primarily mediated by serotonin (5-HT), but also by dopamine (DA) and possibly noradrenaline (NA). In humans, however, the neurochemical and neurophysiological basis of acute MDMA effects remains unknown. The distributi...
متن کاملEffect of carvacrol on pulmonary function tests, and total and differential white blood cell counts in healthy volunteers: A randomized clinical trial
Objective: This is the first study to evaluate the effect of carvacrol on pulmonary function tests (PFT), and total and differential white blood cell (WBC) counts in healthy volunteers. Materials and Methods: Thirty healthy volunteers were recruited based on the inclusion and exclusion criteria. The subjects were treated with two doses of carvacrol (1 and 2 mg/kg/day) for 1 month. Total and di...
متن کاملBlood Glucose Lowering Effects of Nigella Sativa L. Seeds Oil in Healthy Volunteers: a Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Background: Several formulations of the Nigella sativa L. seeds (Black seed) have been used in traditional medicine for treatment and prevention of a wide range of diseases including diabetes. But blood glucose lowering effects of its oil in a clinical study is of an interest. Objective: The present study was undertaken to explore the possible blood glucose lowering effects of the Black seed o...
متن کامل