DWI of carotid atheroma - detection of lipid rich necrotic core
نویسندگان
چکیده
V. E. Young, A. J. Patterson, U. Sadat, D. J. Bowden, M. J. Graves, A. N. Priest, T. Y. Tang, J. N. Skepper, P. J. Kirkpatrick, and J. H. Gillard University Department of Radiology, Addenbrookes Hospital, Cambridge, Cambridgeshire, United Kingdom, Department of Medical Physics, Addenbrookes Hospital, Cambridge, Cambridgeshire, United Kingdom, Multi-imaging Centre, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom, Department of Neurosurgery, Addenbrookes Hospital, Cambridge, Cambridgeshire, United Kingdom
منابع مشابه
High-resolution 3d Diffusion Mri: Detection of Lipid-rich Necrotic Core in Plaques without Contrast Media
Purpose: Large lipid-rich necrotic core (LRNC) is a well-known feature of rupture-prone atherosclerotic plaque , which is the major cause of both stroke and transient ischemic attack. Plaque lipid content has also been used clinically to monitor disease progression and the results of therapeutic interventions. Although contrast-enhanced (CE) MRI was shown possible for LRNC detection, patients w...
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BACKGROUND Previous studies suggest that erythrocyte membranes from intraplaque hemorrhage into the necrotic core are a source of free cholesterol and may become a driving force in the progression of atherosclerosis. We have shown that MRI can accurately identify carotid intraplaque hemorrhage and precisely measure plaque volume. We tested the hypothesis that hemorrhage into carotid atheroma st...
متن کاملHemorrhage and large lipid-rich necrotic cores are independently associated with thin or ruptured fibrous caps: an in vivo 3T MRI study.
OBJECTIVE Histological studies suggest associations between hemorrhage and large lipid-rich/necrotic cores with thin or ruptured fibrous caps in advanced atherosclerosis. We investigated these associations in carotid arteries with mild to severe stenosis by in vivo 3T MRI. METHODS AND RESULTS Seventy-seven patients with >or=50% carotid stenosis in at least one side by duplex ultrasound underw...
متن کاملHemorrhage and Large Lipid-Rich Necrotic Cores Are Independently Associated With Thin or Ruptured Fibrous Caps
Objective—Histological studies suggest associations between hemorrhage and large lipid-rich/necrotic cores with thin or ruptured fibrous caps in advanced atherosclerosis. We investigated these associations in carotid arteries with mild to severe stenosis by in vivo 3T MRI. Methods and Results—Seventy-seven patients with 50% carotid stenosis in at least one side by duplex ultrasound underwent bi...
متن کاملIn vivo accuracy of multispectral magnetic resonance imaging for identifying lipid-rich necrotic cores and intraplaque hemorrhage in advanced human carotid plaques.
BACKGROUND High-resolution MRI has been shown to be capable of identifying plaque constituents, such as the necrotic core and intraplaque hemorrhage, in human carotid atherosclerosis. The purpose of this study was to evaluate differential contrast-weighted images, specifically a multispectral MR technique, to improve the accuracy of identifying the lipid-rich necrotic core and acute intraplaque...
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