Synthesis and characterization of a cell-permeable near-infrared fluorescent deoxyglucose analogue for cancer cell imaging.

نویسندگان

  • Marc Vendrell
  • Animesh Samanta
  • Seong-Wook Yun
  • Young-Tae Chang
چکیده

We report the synthesis and characterization of a novel NIR fluorescent deoxyglucose analogue, CyNE 2-DG. Experiments in different cell lines showed a preferential uptake of CyNE 2-DG in cancer cells and its effective competition with unlabeled d-glucose. Cell imaging experiments demonstrated the superior cell-permeability of CyNE 2-DG over the NIR standard IRDye 800CW 2-DG, and validated its application for cancer cell imaging in the NIR region.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 9 13  شماره 

صفحات  -

تاریخ انتشار 2011