Synthesis, Characterization and Biological Studies on some Derivatives of N- (4-Aminobenzenesulphonyl)Morpholine Carrying Amino Acid, Alkoxy and Triazole Moieties

The reaction of N-[4-(chloroacetyl)aminobenzenesulphonyl]morpholine (IV) in acetone or dimethyl-formamide with amine derivatives, 4-aminotriazoles (I,II) or sulpha drugs yielded the corresponding N-[4-(substituted glycyl)aminobenzenesulphonyl]-morpholine derivatives (V-XV). Moreover, some derivatives of N-[4-(alkoxyacetyl)aminobenzenesulphonyl]morpholine (XVI-XXI) were synthesized. The reaction of XI with the requisite aromatic aldehydes in methanol gave Schiff bases (XXII,XXIII). Coupling reaction between (III) and Phtor Tos-amino acids using the phosphorus oxychloride method furnished the corresponding N-[4-(phtor Tos-Jaminoacyl)aminobenzenesulphonyl] morpholines (XXIV-XXIX). All the synthesized compounds were characterized by IR, 1H-NMR, MS spectral data and elemental analyses and investigated their antibacterial and antifungal activities.