Assessment of beta-cell function in humans, simultaneously with insulin sensitivity and hepatic extraction, from intravenous and oral glucose tests.

E-00421-2006.r1 Assessment of Beta Cell Function in Humans, Simultaneously with Insulin Sensitivity and Hepatic Extraction, from Intravenous and Oral Glucose Test

The Oral Minimal Model Method

The simultaneous assessment of insulin action, secretion, and hepatic extraction is key to understanding postprandial glucose metabolism in nondiabetic and diabetic humans. We review the oral minimal method (i.e., models that allow the estimation of insulin sensitivity, β-cell responsivity, and hepatic insulin extraction from a mixed-meal or an oral glucose tolerance test). Both of these oral t...

Assessment of -cell function in humans, simultaneously with insulin sensitivity and hepatic extraction, from intravenous and oral glucose tests

Claudio Cobelli, Gianna Maria Toffolo, Chiara Dalla Man, Marco Campioni, Paolo Denti, Andrea Caumo, Peter Butler, and Robert Rizza Department of Information Engineering, University of Padua, Padua, Italy; San Raffaele Scientific Institute, Milan, Italy; Larry Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, California; and Division of Endoc...

Quantitative Assessment of Proliferative Effects of Oral Vanadium on Pancreatic Islet Volumes and Beta Cell Numbers of Diabetic Rats

Background: Oral vanadyl sulfate (vanadium) induces normoglycemia, proliferates beta cells and prevents pancreatic islet atrophy in streptozotocin-induced diabetic rats. Soteriological method is used to quantitate the proliferative effects of vanadium on beta-cell numbers and islet volumes of normal and diabetic rats. Methods: Adult male Sprague-Dawley rats were made diabetic with intravenous s...

The changes of serum insulin in response to resistance training with emphasis on FOXO1 in pancreas of diabetes rats

Introduction: Decreased insulin sensitivity and its secretion of pancreas increase the risk of developing type 2 diabetes (T2D). In the present study it was aimed to assess the effect of resistance training on Forkhead box protein O1 (FOXO1) expression in pancreas tissue, serum insulin, and insulin sensitivity in obese rats with T2D. Materials and Methods: T2D was induced by high fa...