P 002 MUC 2 mucin is associated with sialyl - Tn antigen in intestinal metaplasia and gastric carcinomas
نویسندگان
چکیده
intestinal metaplasia and gastric carcinomas Tim Conze1*, Ana Sofia Carvalho2*, Ulf Landegren1, Raquel Almeida2,3, Celso A. Reis2,3, Leonor David2,3 and Ola Söderberg 1 Department of Genetics and Pathology, University of Uppsala, Uppsala, Sweden 2 Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal 3 Medical Faculty of the University of Porto, Porto, Portugal * These authors contributed equally to this work.
منابع مشابه
MUC2 mucin is a major carrier of the cancer-associated sialyl-Tn antigen in intestinal metaplasia and gastric carcinomas.
Changes in mucin protein expression and in glycosylation are common features in pre-neoplastic lesions and cancer and are therefore used as cancer-associated markers. De novo expression of intestinal mucin MUC2 and cancer-associated sialyl-Tn antigen are frequently observed in intestinal metaplasia (IM) and gastric cancer. However, despite that these antigens often co-localize, MUC2 has not bee...
متن کاملST6GalNAc-I controls expression of sialyl-Tn antigen in gastrointestinal tissues.
Sialyl-Tn is a simple mucin-type carbohydrate antigen aberrantly expressed in gastrointestinal adenocarcinomas and in the precursor lesion intestinal metaplasia. Sialyl-Tn tumour expression is an independent indicator of poor prognosis. We have previously shown in vitro that ST6GalNAc-I and ST6GalNAc-II sialyltransferases can synthesize sialyl-Tn. The aim of the present study was to establish w...
متن کاملAltered glycosylation of the MUC-1 protein core contributes to the colon carcinoma-associated increase of mucin-bound sialyl-Lewis(x) expression.
The mucin carbohydrate epitope sialyl-Le(x), detected with the monoclonal antibody AM-3, is strongly overexpressed in > 90% of human colon carcinomas. We show here that in colon carcinoma one of the mucin cores bearing the sialyl-Le(x) group is MUC-1, whereas sialyl-Le(x) present in normal colon is not detectable on MUC-1. The amounts of MUC-1 core detectable with the monoclonal antibody BC3 in...
متن کاملLigation-mediated Molecular Analysis of Influenza Subtypes, Splicing and Protein Glycosylation
Conze, T. 2010. Ligation-mediated Molecular Analysis of Influenza Subtypes, Splicing and Protein Glycosylation. Acta Universitatis Upsaliensis. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 532. 39 pp. Uppsala. ISBN 978-91-554-7743-1. Binder-based assays are employed throughout the life sciences. Powerful signal amplification techniques have enabled detec...
متن کاملمقایسه موسین موجود در سلولهای مخاط معده بیماران مبتلا به گاستریت هلیکوباکترپیلوری با افراد طبیعی
ABSTRACT Gastric cancer (GC) is one of the most common cancers in the world. Despite some improvement in the treatment of this type of cancer, the 5-year survival rate has been already remained low. Therefore further exploration of biological features and causes of gastric cancer is needed to reduce its occurrence. In sequential changes from superficial gastritis to dysplasia and cance...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2009