A clinical threat in patients with granulomatosis polyangiitis in remission: Subglottic stenosis
نویسندگان
چکیده
Introduction Granulomatosis with polyangiitis (GPA) (Wegener’s granulomatosis) is a systemic necrotizing disease that involves the main upper and lower respiratory tracts and results in pauci-immune glomerulonephritis in the kidneys and areas supplied by smalland medium-sized arteries (1). If the disease is localized only to the upper respiratory tract or lungs, it is defined as a limited form and constitutes one-fourth of cases. Some of these cases may then progress to the systemic form (2).
منابع مشابه
Clinical characteristics and treatment of subglottic stenosis in patients with Wegener’s granulomatosis
Subglottic stenosis is a complication of Wegener’s granulomatosis caused by tracheal tissue damage and scarring. It may occur as a presenting feature of the disease leading to diagnosis, or instead as a late-stage manifestation. Frequently, it occurs or progresses independently of other features of active disease, and sometimes appears while the general disease is in remission under therapy. Th...
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PURPOSE Wegener's granulomatosis (WG) is a rare multisystem inflammatory disease, which infrequently involves the subglottic area and trachea. Treatment usually involves the use of immunosuppressive agents with corticosteroids. Some patients, however, continue to have symptoms of airway obstruction after clinical remission following the standard therapeutic regimen. OBJECTIVE To investigate l...
متن کامل[Subglottic stenosis in Wegener's granulomatosis].
OBJECTIVE Describe the management of subglottic stenosis in a patient with Wegener's granulomatosis. MATERIAL AND METHOD Case report. RESULTS We report the case of a 26-year-old woman who presented Wegener granulomatosis and subglottic stenosis, with renal, skin, oropharyngeal, nasal, and paranasal locations. Medical treatment had cured all the locations except the subglottic stenosis. An e...
متن کامل[Subglottic stenosis in Wegener's granulomatosis--a diagnostic and therapeutic problem].
Wegener's granulomatosis (WG) is a disease caused by necrotising vasculitis of small and middle blood vessels of upper and lower respiratory tract and kidneys of unknown etiology. ENT symptoms develop in more than 90% of patients and tracheobronchial involvement occurs in about 20% of patients, most often as a subglottic stenosis. Subglottic stenosis occurs usually as a late complication of dis...
متن کاملSubglottic stenosis: a ten-year review of treatment outcomes.
OBJECTIVES/HYPOTHESIS To evaluate the endoscopic surgical management of adult subglottic stenosis and describe treatment outcomes. STUDY DESIGN Retrospective review. METHODS Ten-year review of adult patients with subglottic stenosis. RESULTS Ninety-two adults (23 male, 69 female) with subglottic stenosis underwent 247 endoscopic dilations between 2001 and 2010. The mean age was 48 years a...
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