Ctk1 function is crucial for efficient translation initiation and interacts with the mRNP processing factor Npl3
نویسندگان
چکیده
Parts of the present thesis are submitted for publication: " Insights into DNA double-strand break repair and ataxia-telangiectasia like disease from the structure of an Mre11-Nbs1 complex " , manuscript in preparation.
منابع مشابه
Monosome formation during translation initiation requires the serine/arginine-rich protein Npl3.
The yeast shuttling serine/arginine-rich protein Npl3 is required for the export of mRNAs and pre-60S ribosomal subunits from the nucleus to the cytoplasm. Here, we report a novel function of Npl3 in translation initiation. A mutation in its C terminus that prevents its dimerization (npl3Δ100) is lethal to cells and leads to translational defects, as shown by [(35)S]methionine incorporation ass...
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