Eccrine Poromatosis: Case Report, Review of the Literature, and Treatment

Eccrine poromas arise from the intraepidermal region of the eccrine sweat duct and most often occur as a benign solitary tumor. There are few reports of the occurrence of multiple lesions, defined as poromatosis, which may present in patients who have undergone radiotherapy and/or polychemotherapy. We report the case of a 43-year-old male with a history of mantle cell lymphoma who had undergone 6 cycles of polychemotherapy. He presented to the dermatology clinic for multiple painful lesions on his palms and soles. Several biopsies were performed consistent with eccrine poromas. The patient was successfully treated with a combination of excision, imiquimod cream, and cryosurgery. This case adds to the literature regarding the pathogenesis and Received: June 16, 2015 Accepted: July 7, 2015 Published online: August 12, 2015 Boni Elewski, MD Department of Dermatology University of Alabama at Birmingham EFH 414, 1530 3rd Ave. South, Birmingham, AL 35294 (USA) E-Mail beelewski @ gmail.com © 2015 S. Karger AG, Basel 2296–9195/15/0012–0095$39.50/0 www.karger.com/sad Established Facts • Eccrine poromas are benign tumors of the eccrine sweat duct. • Multiple eccrine poromas, or eccrine poromatosis, may occur in association with polychemotherapy.