Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells.
نویسندگان
چکیده
A novel molecule T1 with efficient intramolecular charge transfer was designed as a fluorescent chemodosimeter for cysteine (Cys) and homocysteine (Hcy). Upon addition of Cys/Hcy, T1 exhibited greatly enhanced fluorescence intensity as well as a large absorption peak shift (70 nm), and can be used for bioimaging of Cys/Hcy in living cells and detection in human plasma by visual color change. The detection mechanism was proved by (1)H NMR, mass spectrometry analysis and Gaussian calculations.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 9 4 شماره
صفحات -
تاریخ انتشار 2011