Identification of the herboxidiene biosynthetic gene cluster in Streptomyces chromofuscus ATCC 49982.
نویسندگان
چکیده
The 53-kb biosynthetic gene cluster for the novel anticholesterol natural product herboxidiene was identified in Streptomyces chromofuscus ATCC 49982 by genome sequencing and gene inactivation. In addition to herboxidiene, a biosynthetic intermediate, 18-deoxy-herboxidiene, was also isolated from the fermentation broth of S. chromofuscus ATCC 49982 as a minor metabolite.
منابع مشابه
Enhancement of herboxidiene production in Streptomyces chromofuscus ATCC 49982.
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ورودعنوان ژورنال:
- Applied and environmental microbiology
دوره 78 6 شماره
صفحات -
تاریخ انتشار 2012