α-Amination of keto-nitrones via multihetero-Cope rearrangement employing an imidoyl chloride reagent.
نویسندگان
چکیده
α-Aminations of ketone-derived nitrones have been developed via [3,3]-rearrangement of the intermediates generated upon condensation with imidoyl chlorides. Careful reagent selection provides synthetically attractive amino protecting groups. The enediamide or α'-carbamoyl enamide products can be hydrolyzed to the desired carbonyl, or exposed to electrophiles for further α-functionalization.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 61 شماره
صفحات -
تاریخ انتشار 2012