Towards an Integrated Microdevice for Liquid Dna Extraction and Amplification Applicable to Forensic Dna Analysis
نویسندگان
چکیده
Historically, most microfluidic devices for genetic analysis have been fabricated in glass, a substrate that is costly and, if not regenerated properly between analyses, can have problems with cross-contamination. The use of polymeric substrates, such as poly(methylmethacrylate) (PMMA), allows for simplified fabrication with the possibility for inexpensive and disposable microdevices. The work presented in this paper demonstrates the use of plastic microdevices for DNA extraction and amplification of buccal swabs applicable to forensic short tandem repeat (STR) analysis, and represents advancement towards less expensive, integrated, disposable devices.
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