Potassium clavulanate
نویسندگان
چکیده
The title salt, K(+)·C(8)H(8)NO(5) (-) [systematic name: potassium (2R,5R,Z)-3-(2-hy-droxy-ethyl-idene)-7-oxo-4-oxa-1-aza-bicyclo-[3.2.0]heptane-2-carb-oxyl-ate], a widely used β-lactam anti-biotic, is usually chemically unstable even in the solid state owing to its tendency to be hydrolysed. In the crystal structure, the potassium cations are arranged along the a axis, forming inter-actions to the carboxyl-ate and hy-droxy groups, resulting in one-dimensional ionic columns. These columns are arranged along the b axis, connected by O-H⋯O hydrogen bonds, forming a layer in the ab plane.
منابع مشابه
Penetration of amoxicillin and potassium clavulanate into the cerebrospinal fluid of patients with inflamed meninges.
A single intravenous dose of 2.0 g of amoxicillin and 0.2 g of potassium clavulanate was given to patients with bacterial meningitis, and the pharmacokinetics of both drugs in the cerebrospinal fluid (CSF) and plasma were evaluated. Twenty-one patients aged 14 to 76 years were studied. Both amoxicillin and potassium clavulanate were detectable in the CSF as early as 1 h and reached peak concent...
متن کاملReverse Phase High Performance Liquid Chromatographic Method for Simultaneous Determination of Cefuroxime Axetil and Potassium Clavulanate in Tablet Dosage Form
A simple, specific, accurate, and precise reverse phase high-performance liquid chromatographic method for analysis of Cefuroxime axetil and Potassium clavulanate has been developed. Separation of drugs was carried out on Jasco HPLC system with Hypersil Gold C-18 column (250 mm × 4.6 mm i.d.), using 0.01M Potassium dihydrogen phosphate: methanol 60: 40 (v/v) as mobile phase. Quantitation of dru...
متن کاملPharmacokinetics of potassium clavulanate in combination with amoxicillin in pediatric patients.
Two dosages of a liquid suspension formulation of amoxicillin and potassium clavulanate were tested in 34 infants and children. The smaller dosage resulted in suboptimal plasma concentrations. With a greater dosage (3.3 mg of clavulanate per kg and 13.3 mg of amoxicillin per kg), the mean peak plasma concentrations were 1.6 micrograms clavulanic acid per ml and 4.9 micrograms amoxicillin per ml.
متن کاملStability of reconstituted amoxicillin clavulanate potassium under simulated in-home storage conditions
Oral suspensions of antibiotics are mainly available as dry powders for reconstitution. Many reconstituted antibiotic suspension is to be kept refrigerated in order to get the optimal benefit from the drug. However, many patients do not keep to the specified storage conditions for different reasons like no refrigerator and irregular power supply that may result in various degrees of degradation...
متن کاملTreatment of Cervical Chlamydial Infection With Amoxicillin/Clavulanate Potassium
OBJECTIVE To determine if amoxicillin/clavulanate potassium is effective in the treatment of Chlamydia trachomatis endocervicitis. METHODS Thirty-two patients with culture-proven endocervical infection were treated with amoxicillin/clavulanate potassium, 500 mg orally 3 times a day for 10 days. Post-treatment endocervical specimens were obtained at 2, 4, and 6 weeks for culture of C. trachoma...
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