Aryl Hydrocarbon Receptor Activation

Role of aryl hydrocarbon receptor in mesenchymal stromal cell activation: A minireview

Mesenchymal stromal cells (MSCs) possess great therapeutic advantages due to their ability to produce a diverse array of trophic/growth factors related to cytoprotection and immunoregulation. MSC activation via specific receptors is a crucial event for these cells to exert their immunosuppressive response. The aryl-hydrocarbon receptor (AhR) is a sensitive molecule for external signals and it i...

Potential roles of the aryl hydrocarbon receptor in female reproductive senescence.

The transition to reproductive senescence involves changes in neuroendocrine and ovarian functions, and is accelerated by activation of the aryl hydrocarbon pathway by environmental toxicants such as 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD). In this article, studies which provide evidence as to the possible mechanisms by which the aryl hydrocarbon receptor (AhR) acts in this capacity (i.e. d...

Activation of the aryl hydrocarbon receptor by some vegetable constituents determined using in vitro reporter gene assay.

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the biological action of many aromatic environmental pollutants. In this study, we investigated the activation of the AhR by some vegetable constituents using the AhR-based bioassay for dioxins, i.e., the chemical activated luciferase gene expression (CALUX) assay. Ninety-five vegetable constituents, in...

Activation of the aryl hydrocarbon receptor by the calcium/calmodulin- dependent protein kinase kinase inhibitor STO-609

Title Page Omeprazole Attenuates Hyperoxic Lung Injury in Mice via Aryl hydrocarbon Receptor Activation, and is Associated with Increased Expression of Cytochrome P4501A Enzymes

Inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol.

We investigated the effect of resveratrol, a constituent of the human diet that has been shown to inhibit aryl hydrocarbon-induced carcinogenesis in animals, on the carcinogen activation pathway regulated by the aryl hydrocarbon receptor. Resveratrol inhibited the metabolism of the environmental aryl hydrocarbon benzo[a]pyrene (B[a]P) catalyzed by microsomes isolated from B[a]P-treated human he...