A structural and primary sequence comparison of the viral RNA-dependent RNA polymerases.
نویسنده
چکیده
A systematic bioinformatic approach to identifying the evolutionarily conserved regions of proteins has verified the universality of a newly described conserved motif in RNA-dependent RNA polymerases (motif F). In combination with structural comparisons, this approach has defined two regions that may be involved in unwinding double-stranded RNA (dsRNA) for transcription. One of these is the N-terminal portion of motif F and the second is a large insertion in motif F present in the RNA-dependent RNA polymerases of some dsRNA viruses.
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ورودعنوان ژورنال:
- Nucleic acids research
دوره 31 7 شماره
صفحات -
تاریخ انتشار 2003