STUDIES ON SEMI-SYNTHETIC 7a-FORMAMIDOCEPHALOSPORINS III. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME
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چکیده
l -yl)carbonylamino]acetamido]-7a:-formamidocephalosporins with various substituents at the C-3 position of the cephalosporin nucleus is described. Inhibition of Gram-positive and Gram-negative bacteria including /Mactamase producing strains was observed with phenyl as the aryl residue. The 3,4-dihydroxyphenyl group further enhanced the activity against Gram-negative organisms; in this series, the 3-[(l-methyl-l#-tetrazol-5-yl)thiomethyl] and 3-[(l -carboxymethyl-l#-tetrazol-5-yl)thiomethyl] analogues (2 and 12b) exhibited exceptional activity against Gram-negative bacteria, including Pseudomonas aeruginosa.
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