Chemical genetics: budding yeast as a platform for drug discovery and mapping of genetic pathways.
نویسنده
چکیده
The budding yeast Saccharomyces cerevisiae is a widely used model organism, and yeast genetic methods are powerful tools for discovery of novel functions of genes. Recent advancements in chemical-genetics and chemical-genomics have opened new avenues for development of clinically relevant drug treatments. Systematic mapping of genetic networks by high-throughput chemical-genetic screens have given extensive insight in connections between genetic pathways. Here, I review some of the recent developments in chemical-genetic techniques in budding yeast.
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عنوان ژورنال:
- Molecules
دوره 17 8 شماره
صفحات -
تاریخ انتشار 2012