Short Title: NO and Endothelial Dysfunction Keywords: diabetes, G-proteins, hypertension, nitric oxide
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منابع مشابه
Therapeutic potential of nitric oxide donors in the prevention and treatment of atherosclerosis.
Well-known risk factors for atherosclerosis include hypercholesterolaemia, hypertension, diabetes, and smoking. These conditions are associated with endothelial dysfunction, which itself is associated with reduced endothelial generation of nitric oxide (NO). This is an overview of the implications of NO generation in atherosclerosis and of the potential therapeutic benefit of drugs which donate...
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Nitric oxide (NO) is the main substance regulating vascular tone. Endothelial dysfunction and decreased production of NO is a well-known phenomenon in adults with cardiovascular disease and especially when concomitant disorders such as diabetes and atherosclerosis are present. However, there are only few data on NO, polymorphisms of endothelial NO synthase (eNOS) and endogenous inhibitors of eN...
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Nitric oxide (NO) is an important regulator of vascular tone, and is also an antithrombotic, anti-inflammatory, antiproliferative, and antiatherogenic factor. Endothelial function is altered in patients with coronary artery disease, stroke, and peripheral artery disease, and endothelial dysfunction correlates with the risk factor profile for a patient. Hypertension and type 2 diabetes are risk ...
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Nitric oxide release from the endothelium plays an important role in regulation of vascular tone, inhibition of both platelet and leukocyte aggregation and adhesion, and inhibition of cell proliferation. These properties suggest that the level of NO production by the endothelium may play a pivotal role in the regulation of vascular disease. Analysis using mass spectrometry has revealed that NO ...
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