Neurourological Application of Neurogenesis and Inflammation and Pain Mechanisms of Rocuronium Bromide

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creative-commons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution , and reproduction in any medium, provided the original work is properly cited. In the present issue of the International Neurourology Journal, 2 interesting topics were included. One is " Current opinion on the role of neurogenesis in the therapeutic strategies for Al-zheimer disease, Parkinson disease, and ischemic stroke; considering neuronal voiding function " [1] and the other is " Ro-curonium bromide inhibits inflammation and pain by suppressing nitric oxide production and enhancing prostaglandin E2 synthesis in endothelial cells " [2]. Alzheimer disease, Parkinson disease, and cerebral infarction are common neurological diseases. Most patients suffering from these disorders experience difficulty in voiding. In Al-zheimer disease, urge incontinence occurs due to detrusor hy-perreflexia. Urinary urgency, urinary frequency, nocturia, and urge incontinence occur complexly in patients with Parkinson disease. In patients with cerebral infarction, retention of urine caused by areflexic bladder, urinary urgency, or urinary frequency caused by detrusor hyperreflexia occurs frequently. However, there is a shortage of satisfactory treatments to control and improve neurogenic bladder induced by such neuro-logical diseases [3,4]. Researches are currently underway in order to develop new neurogenic bladder treatments, and some researchers have reported that nerve stimulation and stem cells improve neuro-genic bladder [5-7]. In order to effectively treat neurogenically dysfunctional bladder, treatments should also prevent functional deterioration of the central nervous system. Adult neuro-genesis is known to generate new nerve cells in the adult hip-pocampal dentate gyrus, thereby sustaining the overall function of the brain by maintaining and improving learning ability and memory function. As adult neurogenesis is proven to help recover of brain damage, researches in adult neurogenesis have been quite actively for hard-to-cure diseases. Integrative adult neurogenesis researches are expected to help improve voiding difficulty, which is commonly found in such neurological diseases. Effects of rocuronium bromide in the vascular wall were also introduced in this issue. Nondepolarizing neuromuscular blocking agent, rocuronium bromide, has been used as an adjunct for relaxation or paralysis of skeletal muscles, facilitation of endotracheal intubation, and improving surgical conditions during general anesthesia [8,9]. The adverse effect of rocuroni-um bromide is injection pain or withdrawal movement. Diverse mechanisms of the adverse effect of rocuronium bromide have been suggested to date, however, the exact mechanisms are still not proved. The authors, demonstrated that rocuronium bromide inhibited endothelial …