Unbalanced globin chain synthesis in congenital dyserythropoietic anemia.

Hematologic evaluation of a 5-yr-old girl from the child and from both of her parents with lifelong anemia demonstrated the an abnormal balance between the synthecharacteristic findings of congenital dyssis of the a and non-a globin components erythropoietic anemia (CDA) type II. of hemoglobin was observed, the a chains Globin chain synthesis was studied in vitro being synthesized in excess. Neither by measuring the incorporation of L-Ieuparent demonstrated microcytosis, hypocine-14C into globin by peripheral blood chromia, or other findings suggestive of and bone marrow erythroid cells. In cells I3-thalassemia trait.