Pentamidine methanesulfonate to be distributed by CDC.
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Structure-activity relationships of analogs of pentamidine against Plasmodium falciparum and Leishmania mexicana amazonensis.
The antiprotozoal compound 1,5-di(4-amidinophenoxy)pentane (pentamidine) and 36 of its analogs were screened for in vitro activity against Leishmania mexicana amazonensis clone 669 C4S (MHOM/BR/73/M2269) and Plasmodium falciparum clones W2 (Indochina III/CDC) and D6 (Sierra Leone I/CDC). Pentamidine and each of the analogs tested exhibited activity in vitro against L. m. amazonensis and P. falc...
متن کاملIn Memoriam: Sandy Ford (1950–2015)
age. To her children, she was a loving mother; to her co-workers, she was a caring human being and dedicated public health worker; to the world, she was a herald of the AIDS epidemic, playing a major role in alerting the world to the onset of this epidemic. In January 1979, Sandy took a position in the Parasitic Diseases Division in the Centers for Disease Control, now the Centers for Disease C...
متن کاملSynthesis and In Vitro Leishmanicidal Effects of Conformationally Restricted Analogues of Pentamidine
Four conformationally restricted analogues of pentamidine were prepared. Then, different concentrations (0.039, 0.078, 0.156, 0.312 and 0.625 mg/mL) of each compound and two positive controls (amphotericin B and pentamidine, 0.625 mg/mL), one negative control (culture medium) and one solvent control (DMSO) were prepared and placed in 24-well plates containing 50000 parasite per well. Promastigo...
متن کاملVulval ulceration associated with foscarnet.
Accepted for publication 27 January 1992 Case report A 34 year old woman with AIDS (CDC IV Cl diseaseextrapulmonary TB April 90) developed CMV retinitis in February 1991. She was treated with foscarnet (200 mg/kg/day after a 20 mg loading dose) given intravenously through a Hickman central line. She was receiving concurrent treatment with oral fluconazole and nebulised pentamidine for candida a...
متن کاملSynthesis and In Vitro Leishmanicidal Effects of Conformationally Restricted Analogues of Pentamidine
Four conformationally restricted analogues of pentamidine were prepared. Then, different concentrations (0.039, 0.078, 0.156, 0.312 and 0.625 mg/mL) of each compound and two positive controls (amphotericin B and pentamidine, 0.625 mg/mL), one negative control (culture medium) and one solvent control (DMSO) were prepared and placed in 24-well plates containing 50000 parasite per well. Promastigo...
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عنوان ژورنال:
- MMWR. Morbidity and mortality weekly report
دوره 33 17 شماره
صفحات -
تاریخ انتشار 1984