Solution NMR Structure of the Ca -bound N-terminal Domain of CaBP7 A REGULATOR OF GOLGI TRAFFICKING*□
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چکیده
Background: CaBP7 is an EF-hand-containing transmembrane protein that inhibits PI4KIII activity. Results: PI4KIII interacts with CaBP7 NTD, which exhibits an expansive hydrophobic pocket. Conclusion: The structure of CaBP7 NTD is similar to that of CaM NTD but has a more expansive hydrophobic pocket containing fewer methionine residues. Significance: Regulation of PI4P synthesis is essential for vesicle trafficking and secretory pathway function.
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تاریخ انتشار 2012