Pharmacokinetics and Pulmonary Disposition of Clarithromycin and Tilmicosin in Foals
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چکیده
منابع مشابه
Oral absorption of clarithromycin is nearly abolished by chronic comedication of rifampicin in foals.
The delivery of clarithromycin (CRL) to its site of action in bronchial/alveolar epithelial cells (EC), bronchial epithelial lining fluid (ELF), and bronchoalveolar lavage cells (BALC) may be influenced by CYP3A4 and the drug transporters, ATP-binding cassette (ABC) B1 and ABCC2 and organic anion-transporting polypeptides (OATPs), which can be modulated and/or up-regulated via the nuclear pregn...
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