A novel general strategy for cloning tumor suppressor genes using radiation-reduced chromosomal superfragments.
نویسندگان
چکیده
To identify the tumor suppressor gene on human chromosome 11p15, we generated mouse microcell hybrids containing small transferable chromosome 11p15 fragments, which we have termed "DNA superfragments". These hybrids will be used to identify which fragments contain a tumor suppressor gene by direct transfer of the fragments to tumor cells via microcell fusion.
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ورودعنوان ژورنال:
- The Tohoku journal of experimental medicine
دوره 168 2 شماره
صفحات -
تاریخ انتشار 1992