Cationic Porphyrin Induced a Telomeric DNA to G-Quadruplex Form in Water
نویسندگان
چکیده
The formation of the DNA G-quadruplex is induced by the addition of a novel porphyrin carrying four cationic tethers. Circular dichroism spectroscopy reveals that the porphyrin binds to Tetrahymena telomeric repeat to form G-quadruplex under stabilizing-cation-deficient and no buffer conditions.
منابع مشابه
Specific recognition and stabilization of monomeric and multimeric G-quadruplexes by cationic porphyrin TMPipEOPP under molecular crowding conditions
Ligands targeting telomeric G-quadruplexs are considered good candidates for anticancer drugs. However, current studies on G-quadruplex ligands focus exclusively on the interactions of ligands and monomeric G-quadruplexes under dilute conditions. Living cells are crowded with biomacromolecules, and the ≈ 200-nucleotide G-rich single-stranded overhang of human telomeric DNA has the potential to ...
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ورودعنوان ژورنال:
- Bioinorganic Chemistry and Applications
دوره 2008 شماره
صفحات -
تاریخ انتشار 2008