Determination of Cremophor EL in Rat Plasma by LC-MS/MS: Application to a Pharmacokinetic Study
نویسندگان
چکیده
Polyoxyethyleneglycerol triricinoleate (Cremophor EL; CrEL) is a liquid product formed by the reaction of ethylene oxide with castor oil at a molar ratio of 35:1 [1]. CrEL is used as a excipient in formulations for the solubilization of various hydrophobic drugs including anesthetics [2], antineoplastic agents [2,3] immunosuppressive agents [4], analgesics [5,6] vitamins [7] and new synthetic water insoluble compounds. Although CrEL is considered relatively nontoxic [2,8], several reports suggest that drugs administered in CrEL induce serious complications like anaphylactoid hypersensitivity [7], axonal swelling, degeneration and demyelination [3,4]. Moreover, it has been proposed that CrEL plays a role in the etiology of peripheral neuropathy observed after intravenous paclitaxel [3] or cyclosporin A treatment and recent evidence supports the notion that CrEL causes nerve conduction [3,9]. Pharmacokinetic disposition of drugs depends on CrEL pharmacokinetics [10].
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