Pharmacological Inhibition of Histone Deacetylases (HDACs) by Suberoylanilide Hydroxamic Acid (SAHA) Specifically Alters Gene Expression and Reduces Ischemic Injury in the Mouse Brain
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Pharmacological inhibition of histone deacetylases by suberoylanilide hydroxamic acid specifically alters gene expression and reduces ischemic injury in the mouse brain.
Pharmacological manipulation of gene expression is considered a promising avenue to reduce postischemic brain damage. Histone deacetylases (HDACs) play a central role in epigenetic regulation of transcription, and inhibitors of HDACs are emerging as neuroprotective agents. In this study, we investigated the effect of the HDAC inhibitor suberoylanilide hydroxamic acid (SAHA) on histone acetylati...
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تاریخ انتشار 2006