Selective Serotonin Reuptake Inhibitors
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چکیده
It has long been postulated that a deficiency in CNS serotonergic activity is the cause of, or a predisposing factor for, depression. [1] However, the evidence for this association is largely circumstantial and it certainly does not represent an adequate and full model for depression, probably due to there being multiple aetiological factors. [2] Some pharmacological trial data also cast doubt on the efficacy of SSRIs compared with placebo. [3] [4] [5] Despite this, manipulation of the serotonin axis by SSRIs seems to be beneficial in treating patients with moderate-to-severe depression.
منابع مشابه
Effect of Donepezil on Cognitive Disorders Due to the Selective Serotonin Reuptake Inhibitors in the Patients with Major Depressive Disorder
Introduction: Many factors cause cognitive impairment, including medication, such as selective serotonine reuptake inhibitor drugs use. On the other hand, many drugs are used in cognitive impairment therapy, including donepezil, which act by inhibiting the cholinesterase enzyme and increase brain acetylcholine. Methods: This study was a double-blind controlled randomized controlled clinical tr...
متن کاملMyoclonus as a Single Side Effect of Combination of Selective Serotonin Reuptake Inhibitors (SSRIs) and Clomipramine: Three Case Reports
Selective Serotonin Reuptake Inhibitors (SSRIs) are the most popular psychiatric medications that are approved for several neuropsychiatric conditions such as depression and obsessive-compulsive disorder (OCD). On the other hand, clomipramine is a tricyclic anti-depressant which is the only approved medication, among this class, to treat OCD due to its substantial effects on serotonergic sys...
متن کاملMeta-analysis of Selective Serotonin Reuptake Inhibitors (SSRIs) Compared to Tricyclic Antidepressants (TCAs) in the Efficacy and Safety of Anti-depression Therapy in Parkinson᾽s Disease(PD) Patients
This meta-analysis aims to assess the efficacy and safety of SSRIs and TCAs in treatment of PD. A computer-base search was conducted of Pubmed, MEDLINE, EMBASE, Cochrane Controlled Trails Register (CCTR) up to December 2011. The random controlled clinic trials about SSRIs and TCAs in PD treatment were collected. Statistical analysis was completed using Review Manager, version 5.0. Five clinic c...
متن کاملMeta-analysis of Selective Serotonin Reuptake Inhibitors (SSRIs) Compared to Tricyclic Antidepressants (TCAs) in the Efficacy and Safety of Anti-depression Therapy in Parkinson᾽s Disease(PD) Patients
This meta-analysis aims to assess the efficacy and safety of SSRIs and TCAs in treatment of PD. A computer-base search was conducted of Pubmed, MEDLINE, EMBASE, Cochrane Controlled Trails Register (CCTR) up to December 2011. The random controlled clinic trials about SSRIs and TCAs in PD treatment were collected. Statistical analysis was completed using Review Manager, version 5.0. Five clinic c...
متن کاملSelective serotonin reuptake inhibitors: infrequent medical adverse effects.
The selective serotonin reuptake inhibitors have a very favorable safety profile. However, because of the wide use of this drug group, even low-frequency adverse effects become more prevalent. This article reviews 5 of these relatively infrequent adverse medical effects associated with the use of selective serotonin reuptake inhibitors: the syndrome of inappropriate antidiuretic hormone secreti...
متن کاملCase-Control Study Examining the Association between Selective Serotonin Reuptake Inhibitors Use and Hepatocellular Carcinoma
Objectives: The purpose of the study was to assess the relationship between selective serotonin reuptake inhibitors use and hepatocellular carcinoma in Taiwan. Methods: Using the database of the Taiwan National Health Insurance Program, we conducted a case-control study to identify 4901 subjects aged 20 years and more with newly diagnosed hepatocellular carcinoma in 2000-2013 as the cases. We r...
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