b-Guanidinopropionic acid extends the lifespan of Drosophila melanogaster via an AMP-activated protein kinase-dependent increase in autophagy
نویسندگان
چکیده
Si Yang, Li-Hong Long, Di Li, Jian-Kang Zhang, Shan Jin, Fang Wang and Jian-Guo Chen Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China The Key Laboratory of Neurological Diseases (HUST), Ministry of Education of China, Wuhan 430030, China Hubei Key Laboratory of Drug Target Researches and Pharmacodynamic Evaluation (HUST), Wuhan 430030, China The Laboratory of Neuropsychiatric Diseases, The Institute of Brain Research, Huazhong University of Science and Technology, Wuhan 430030, China College of Life Science, Hubei University, Wuhan 430062, China Summary
منابع مشابه
β‐Guanidinopropionic acid extends the lifespan of Drosophila melanogaster via an AMP‐activated protein kinase‐dependent increase in autophagy
Previous studies have demonstrated that AMP-activated protein kinase (AMPK) controls autophagy through the mammalian target of rapamycin (mTOR) and Unc-51 like kinase 1 (ULK1/Atg1) signaling, which augments the quality of cellular housekeeping, and that β-guanidinopropionic acid (β-GPA), a creatine analog, leads to a chronic activation of AMPK. However, the relationship between β-GPA and aging ...
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تاریخ انتشار 2015