Title : Nipah virus envelope pseudotyped lentiviruses efficiently target ephrinB 2 + stem cell
نویسندگان
چکیده
word count: 249 words 21 Text word count (excluding references, table footnotes and figure legends): 7,277 words 22 Copyright © 2012, American Society for Microbiology. All Rights Reserved. J. Virol. doi:10.1128/JVI.02032-12 JVI Accepts, published online ahead of print on 28 November 2012 on O cber 8, 2017 by gest http/jvi.asm .rg/ D ow nladed fom on O cber 8, 2017 by gest http/jvi.asm .rg/ D ow nladed fom on O cber 8, 2017 by gest http/jvi.asm .rg/ D ow nladed fom
منابع مشابه
Nipah virus envelope-pseudotyped lentiviruses efficiently target ephrinB2-positive stem cell populations in vitro and bypass the liver sink when administered in vivo.
Sophisticated retargeting systems for lentiviral vectors have been developed in recent years. Most seek to suppress the viral envelope's natural tropism while modifying the receptor-binding domain such that its tropism is determined by the specificity of the engineered ligand-binding motif. Here we took advantage of the natural tropism of Nipah virus (NiV), whose attachment envelope glycoprotei...
متن کاملpseudotyped lentiviruses efficiently target ephrinB 2 + stem cell
word count: 249 words 21 Text word count (excluding references, table footnotes and figure legends): 7,277 words 22 Copyright © 2012, American Society for Microbiology. All Rights Reserved. J. Virol. doi:10.1128/JVI.02032-12 JVI Accepts, published online ahead of print on 28 November 2012 on O cber 6, 2017 by gest http/jvi.asm .rg/ D ow nladed fom on O cber 6, 2017 by gest http/jvi.asm .rg/ D o...
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The henipaviruses, Nipah virus (NiV) and Hendra virus (HeV), are lethal emerging paramyxoviruses. EphrinB2 and ephrinB3 have been identified as receptors for henipavirus entry. NiV and HeV share similar cellular tropisms and likely use an identical receptor set, although a quantitative comparison of receptor usage by NiV and HeV has not been reported. Here we show that (i) soluble NiV attachmen...
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The cytoplasmic tails of the envelope proteins from multiple viruses are known to contain determinants that affect their fusogenic capacities. Here we report that specific residues in the cytoplasmic tail of the Nipah virus fusion protein (NiV-F) modulate its fusogenic activity. Truncation of the cytoplasmic tail of NiV-F greatly inhibited cell-cell fusion. Deletion and alanine scan analysis id...
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Oncoretrovirus vectors pseudotyped with the feline endogenous retrovirus (RD114) envelope protein produced by the FLYRD18 packaging cell line have previously been shown to transduce human hematopoietic progenitor cells with a greater efficiency than similar amphotropic envelope-pseudotyped vectors. In this report, we describe the production and efficient concentration of RD114-pseudotyped murin...
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