A Rare Case of Castleman’s Disease of Plasma Cell Type Complicated with Membranoproliferative Glomerulonephritis

Castleman’s disease (CD) is an uncommon atypical lymphoproliferative disorder with different histological and clinical forms. Patients with the plasma cell type frequently present with systemic symptoms; including fever, weight loss, hemolytic anemia, hypoalbuminemia, hypergammaglobulinemia and increased acute-phase proteins. Renal manifestations like proteinuria or hematuria are common in Castleman’s disease (CD); however, renal complications including minimal change disease, mesangial proliferative glomerulonephritis, membranous glomerulonephritis and nephrotic syndrome also rarely associates with CD. We herein report a patient with fever, weight loss and increase in inflammatory proteins, anemia and declined renal function that was diagnosed as multicentric type CD associated with membranoproliferative glomerulonephritis.