Engineered cationic antimicrobial peptides to overcome multidrug resistance by ESKAPE pathogens.
نویسندگان
چکیده
Multidrug resistance constitutes a threat to the medical achievements of the last 50 years. In this study, we demonstrated the abilities of two de novo engineered cationic antibiotic peptides (eCAPs), WLBU2 and WR12, to overcome resistance from 142 clinical isolates representing the most common multidrug-resistant (MDR) pathogens and to display a lower propensity to select for resistant bacteria in vitro compared to that with colistin and LL37. The results warrant an exploration of eCAPs for use in clinical settings.
منابع مشابه
Rational design of engineered cationic antimicrobial peptides consisting exclusively of arginine and tryptophan, and their activity against multidrug-resistant pathogens.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 59 2 شماره
صفحات -
تاریخ انتشار 2015