BRCA1, Hormone, and Tissue-Specific Tumor Suppression

نویسنده

  • Yanfen Hu
چکیده

Germline mutations of BRCA1 predispose women to breast and ovarian cancers. Elucidating molecular mechanism of tissue- and gender-specific phenomena in BRCA1-related tumors is a key to our understanding of BRCA1 function in tumor suppression. This review summarizes studies in recent years on the link between BRCA1 and estrogen/progesterone signaling pathways, as well as discusses various models underscoring a triangle relationship among BRCA1, estrogen and genome instability.

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عنوان ژورنال:
  • International Journal of Biological Sciences

دوره 5  شماره 

صفحات  -

تاریخ انتشار 2009