Clinical relevance of MDM2 SNP 309 and TP53 Arg72Pro in follicular lymphoma.
نویسندگان
چکیده
David Wrench, Rachel Waters, Emanuela Carlotti, Sameena Iqbal, Janet Matthews, Marie Calaminici, John Gribben, T Andrew Lister, Jude Fitzgibbon Centre for Medical Oncology, Barts and the London School of Medicine, London, UK; Centre for Statistics in Medicine, University of Oxford, Oxford, UK; Data Management Unit, Medical Oncology Department, Barts and the London NHS Trust, London, UK; Histopathology Department, Barts and the London NHS Trust, London, UK. Citation: Wrench D, Waters R, Carlotti E, Iqbal S, Matthews J, Calaminici M, Gribben J, Lister TA, Fitzgibbon J. Clinical relevance of MDM2 SNP 309 and TP53 Arg72Pro in follicular lymphoma. Haematologica 2009. doi: 10.3324/haematol.13533
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| 150 | haematologica | 2009; 94(1) MDM2 SNP 309 can lead to earlier onset or more advanced disease and TP53 negatively regulates MDM2 expression, we assessed MDM2 SNP 309 alleles in isolation or in combination with TP53 Arg72Pro alleles against these clinical parameters; there was no evidence of any association (illustrated in Table 1 for gender, stage and responses to therapy; p≥0.13). Kaplan...
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Single-nucleotide polymorphisms (SNPs) of TP53 (codon 72, rs1042522) and MDM2 promoter (SNP 309, rs2279744) have been associated with risk for various human cancers. However, studies analyzing these polymorphisms in pancreatic ductal adenocarcinoma (PDAC) are lacking. We investigated TP53 codon 72 and MDM2 SNP 309 polymorphisms in 32 patients with PDAC, 16 patients with chronic pancreatitis (CP...
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عنوان ژورنال:
- Haematologica
دوره 94 1 شماره
صفحات -
تاریخ انتشار 2009