The Impact of Statins on Biological Characteristics of Stem Cells Provides a Novel 1 Explanation for Their Pleiotropic Beneficial and Adverse Clinical Effects
نویسندگان
چکیده
Applied Stem Cell Laboratory, Heart and Vascular Institute, Department of Medicine, Tulane 6 University Health Sciences Center; New Orleans, LA, USA. 7 Department of Surgery, Tulane University Health Sciences Center; New Orleans, LA, USA. 8 Department of Pharmacology, Tulane University Health Sciences Center; New Orleans, LA, 9 USA. 10 11 12 13 Running Head: Impact of statins on the stem cells potential. 14 15 16 Correspondence to: 17 18 Eckhard U. Alt MD, PhD 19 Director of Cardiovascular Research 20 Heart and Vascular Institute 21 Tulane University Health Sciences Center 22 1430 Tulane Avenue, SL-48, Room 9520, 23 New Orleans, LA, 70112 24 Tel: (504) 988-3040; Fax: (504) 988-8634 25 Email: [email protected] 26 27 28 *Equally Contributing Authors 29 30 31 32 33 Articles in PresS. Am J Physiol Cell Physiol (July 29, 2015). doi:10.1152/ajpcell.00406.2014
منابع مشابه
The impact of statins on biological characteristics of stem cells provides a novel explanation for their pleiotropic beneficial and adverse clinical effects.
Statins reduce atherosclerotic events and cardiovascular mortality. Their side effects include memory loss, myopathy, cataract formation, and increased risk of diabetes. As cardiovascular mortality relates to plaque instability, which depends on the integrity of the fibrous cap, we hypothesize that the inhibition of the potential of mesenchymal stem cells (MSCs) to differentiate into macrophage...
متن کاملCALL FOR PAPERS Stem Cell Physiology and Pathophysiology The impact of statins on biological characteristics of stem cells provides a novel explanation for their pleiotropic beneficial and adverse clinical effects
Reza Izadpanah,* Deborah J. Schächtele,* Andreas B. Pfnür, Dong Lin, Douglas P. Slakey, Philip J. Kadowitz, and Eckhard U. Alt Applied Stem Cell Laboratory, Heart and Vascular Institute, Department of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana; Department of Surgery, Tulane University Health Sciences Center, New Orleans, Louisiana; and Department of Pharmacology,...
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