Quantitative characterization of chick thymus and bursa development.
نویسندگان
چکیده
maminals has becomiw fairly clearls’ established in recent years.’ ‘ The relation between the thymus and immunologic phenomena, moreover, appears to hold for vertebrates in general with the exception of some lower cyclostomata.1 In birds, however, two organs-the thymus and the bursa of Fabricitis-have both been implicated ill the development of immune competence;4’ it has been suggested, although not clearly established, that the two organs perform two distinct functions, the thymus being responsible for cellbound immunity such as the homograft reaction and the bursa being involved in the development of the ability to produce humoral antibodies.’ Studies by Ball7 have demonstrated that the differentiation of mouse embryonic thymus rudiments can be described in quantitative terms by the use of a Coulter Counter and Cell Analyzer. This method takes advantage of the fact that the mature small lymphocyte is considerably smaller in volume than the large lymphocytes and lymphohlast cells from which they originate. Recently this method was applied by Peterson and Good8 to briefly describe chicken thymus and bursa development, but their utilization of cells pooled from different thymic lobes and their inability to obtain embryonic bursal cell sus-
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عنوان ژورنال:
- Blood
دوره 27 3 شماره
صفحات -
تاریخ انتشار 1966