Title: Different Types of Retinal Inhibition Have Distinct Neurotransmitter Release Properties Running Title: Ca 2+ -buffering Differentially Affects Amacrine Cell Release
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Title: Different types of retinal inhibition have distinct neurotransmitter release properties 1 Running Title: Ca-buffering differentially affects amacrine cell release 2 Authors: Johnnie M. Moore-Dotson, Justin S. Klein, Reece E. Mazade, Erika D. Eggers 3 Department of Physiology, University of Arizona, Tucson, AZ 85724 4 Department of Biomedical Engineering, University of Arizona, Tucson, AZ 85724 5 Graduate Interdisciplinary Program in Physiological Sciences, University of Arizona, Tucson, 6 AZ 85724 7 Correspondence should be addressed to Erika D. Eggers, Dept. of Physiology, University of 8 Arizona, P.O. Box 245051, Tucson, AZ 85724; [email protected] 9
منابع مشابه
Different types of retinal inhibition have distinct neurotransmitter release properties.
Neurotransmitter release varies between neurons due to differences in presynaptic mechanisms such as Ca(2+) sensitivity and timing. Retinal rod bipolar cells respond to brief dim illumination with prolonged glutamate release that is tuned by the differential release of GABA and glycine from amacrine cells in the inner retina. To test if differences among types of GABA and glycine release are du...
متن کاملSlow changes in Ca2(+) cause prolonged release from GABAergic retinal amacrine cells.
The timing of neurotransmitter release from neurons can be modulated by many presynaptic mechanisms. The retina uses synaptic ribbons to mediate slow graded glutamate release from bipolar cells that carry photoreceptor inputs. However, many inhibitory amacrine cells, which modulate bipolar cell output, spike and do not have ribbons for graded release. Despite this, slow glutamate release from b...
متن کاملSlow changes in Ca cause prolonged release from GABAergic retinal amacrine cells
Eggers ED, Klein JS, Moore-Dotson JM. Slow changes in Ca cause prolonged release from GABAergic retinal amacrine cells. J Neurophysiol 110: 709–719, 2013. First published May 8, 2013; doi:10.1152/jn.00913.2012.—The timing of neurotransmitter release from neurons can be modulated by many presynaptic mechanisms. The retina uses synaptic ribbons to mediate slow graded glutamate release from bipola...
متن کاملAcetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells
Acetylcholine (ACh) is a major retinal neurotransmitter that modulates visual processing through a large repertoire of cholinergic receptors expressed on different retinal cell types. ACh is released from starburst amacrine cells (SACs) under scotopic conditions, but its effects on cells of the rod pathway have not been investigated. Using whole-cell patch clamp recordings in slices of rat reti...
متن کاملReceptor and transmitter release properties set the time course of retinal inhibition.
Synaptic inhibition is determined by the properties of postsynaptic receptors, neurotransmitter release, and clearance, but little is known about how these factors shape sensation-evoked inhibition. The retina is an ideal system to investigate inhibition because it can be activated physiologically with light, and separate inhibitory pathways can be assayed by recording from rod bipolar cells th...
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تاریخ انتشار 2015